New York


Queste pubblicazioni rappresentano il frutto di lavori collaborativi, prevalentemente con i gruppi di Margherita Bignami ed Eugenia Dogliotti, ma anche con Pietro Pichierri e Annapaola Franchitto.


Aquilina, G, Crescenzi, M, and Bignami, M. Mismatch repair, G(2)/M cell cycle arrest and lethality after DNA damage. Carcinogenesis 20:2317-2326, 1999.

Aquilina, G, Ceccotti, S, Martinelli, S, Soddu, S, Crescenzi, M, Branch, P, Karran, P, and Bignami, M. Mismatch repair and p53 independently affect sensitivity to N-(2- chloroethyl)-N'-cyclohexyl-N-nitrosourea. Clin Cancer Res 6:671-680, 2000.

Fiumicino, S, Martinelli, S, Colussi, C, Aquilina, G, Leonetti, C, Crescenzi, M, and Bignami, M. Sensitivity to DNA cross-linking chemotherapeutic agents in mismatch repair-defective cells in vitro and in xenografts. Int J Cancer 85:590-596, 2000.

Colussi, C, Parlanti, E, Degan, P, Aquilina, G, Barnes, D, Macpherson, P, Karran, P, Crescenzi, M, Dogliotti, E, and Bignami, M. The Mammalian Mismatch Repair Pathway Removes DNA 8-oxodGMP Incorporated from the Oxidized dNTP Pool. Curr Biol 12:912-918, 2002.

Franchitto, A, Pichierri, P, Piergentili, R, Crescenzi, M, Bignami, M, and Palitti, F. The mammalian mismatch repair protein MSH2 is required for correct MRE11 and RAD51 relocalization and for efficient cell cycle arrest induced by ionizing radiation in G2 phase. Oncogene 22:2110-2120, 2003.

Pascucci, B, Russo, MT, Crescenzi, M, Bignami, M, and Dogliotti, E. The accumulation of MMS-induced single strand breaks in G1 phase is recombinogenic in DNA polymerase beta defective mammalian cells. Nucleic Acids Res 33:280-288, 2005.

Narciso, L, Fortini, P, Pajalunga, D, Franchitto, A, Liu, P, Degan, P, Frechet, M, Demple, B, Crescenzi, M, and Dogliotti, E. Terminally differentiated muscle cells are defective in base excision DNA repair and hypersensitive to oxygen injury. Proceedings of the National Academy of Sciences of the United States of America 104:17010-17015, 2007.

De Luca, G, Russo, MT, Degan, P, Tiveron, C, Zijno, A, Meccia, E, Ventura, I, Mattei, E, Nakabeppu, Y, Crescenzi, M, Pepponi, R, Pezzola, A, Popoli, P, and Bignami, M. A role for oxidized DNA precursors in Huntington's disease-like striatal neurodegeneration. PLoS genetics 4:e1000266, 2008.

Fortini, P, Ferretti, C, Pascucci, B, Narciso, L, Pajalunga, D, Puggioni, EM, Castino, R, Isidoro, C, Crescenzi, M, and Dogliotti, E. DNA damage response by single-strand breaks in terminally differentiated muscle cells and the control of muscle integrity. Cell Death Differ 19:1741-1749, 2012.

Murfuni, I, Nicolai, S, Baldari, S, Crescenzi, M, Bignami, M, Franchitto, A, and Pichierri, P. The WRN and MUS81 proteins limit cell death and genome instability following oncogene activation. Oncogene 32:610-620, 2013.

De Luca, G, Ventura, I, Sanghez, V, Russo, MT, Ajmone-Cat, MA, Cacci, E, Martire, A, Popoli, P, Falcone, G, Michelini, F, Crescenzi, M, Degan, P, Minghetti, L, Bignami, M, and Calamandrei, G. Prolonged lifespan with enhanced exploratory behavior in mice overexpressing the oxidized nucleoside triphosphatase hMTH1. Aging Cell 12:695-705, 2013.



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