Miotubo riattivato (Pajalunga et al., J Cell Biol 2007)
Il filo conduttore di questa sezione è la ricerca dei rapporti fra controllo del ciclo cellulare e differenziamento terminale. I titoli dei lavori che considero più importanti sono evidenziati in rosso.
Crescenzi, M, Fleming, TP, Lassar, AB, Weintraub, H, and Aaronson, SA. MyoD induces growth arrest independent of differentiation in normal and transformed cells. Proc Natl Acad Sci USA 87:8442-8446, 1990.
Crescenzi, M, Soddu, S, Sacchi, A, and Tato', F. Adenovirus infection induces reentry into the cell cycle of terminally differentiated skeletal muscle cells. Ann N Y Acad Sci 752:9-18, 1995.
Crescenzi, M, Soddu, S, and Tato', F. Mitotic cycle reactivation in terminally differentiated cells by adenovirus infection. J Cell Physiol 162:26-35, 1995.
Farina, A, Gaetano, C, Crescenzi, M, Puccini, F, Manni, I, Sacchi, A, and Piaggio, G. The inhibition of cyclin B1 gene transcription in quiescent NIH3T3 cells is mediated by an E-box. Oncogene 13:1287-1296, 1996.
Scardigli, R, Soddu, S, Falcioni, R, Crescenzi, M, Cimino, L, and Sacchi, A. The beta 4 integrin subunit is expressed in mouse fibroblasts and modulated by transforming growth factor-beta 1. Exp Cell Res 227:223-229, 1996.
Soddu, S, Blandino, G, Scardigli, R, Martinelli, R, Rizzo, MG, Crescenzi, M, and Sacchi, A. Wild-type p53 induces diverse effects in 32D cells expressing different oncogenes. Mol Cell Biol 16:487-495, 1996.
Soddu, S, Blandino, G, Scardigli, R, Rizzo, MG, Coen, S, Bossi, G, Crescenzi, M, and Sacchi, A. Interference with p53 protein inhibits hematopoietic and muscle differentiation. J Cell Biol 134:193-204, 1996.
Tiainen, M, Pajalunga, D, Ferrantelli, F, Soddu, S, Salvatori, G, Sacchi, A, and Crescenzi, M. Terminally differentiated skeletal myotubes are not confined in G0, but can enter G1 upon growth factor stimulation. Cell Growth Diff 7:1039-1050, 1996.
Tiainen, M, Spitkovsky, D, Jansen-Dürr, P, Sacchi, A, and Crescenzi, M. Expression of E1A in terminally differentiated muscle cells reactivates the cell cycle and suppresses tissue-specific genes by separable mechanisms. Mol Cell Biol 16:5302-5312, 1996.
Martinelli, R, Blandino, G, Scardigli, R, Crescenzi, M, Lombardi, D, Sacchi, A, and Soddu, S. Oncogenes belonging to the CSF-1 transduction pathway direct p53 tumor suppressor effects to monocytic differentiation in 32D cells. Oncogene 15:607-611, 1997.
Lattanzi, L, Salvatori, G, Coletta, M, Sonnino, C, Cusella De Angelis, MG, Gioglio, L, Murry, CE, Kelly, R, Ferrari, G, Molinaro, M, Crescenzi, M, Mavilio, F, and Cossu, G. High efficiency myogenic conversion of human fibroblasts by adenoviral vector-mediated MyoD gene transfer. J Clin Invest 101:2119-2128, 1998.
Pajalunga, D, Tognozzi, D, Tiainen, M, D'Angelo, M, Ferrantelli, F, Helin, K, Sacchi, A, and Crescenzi, M. E2F activates late-G1 events but cannot replace E1A in inducing S phase in terminally differentiated skeletal muscle cells. Oncogene 18:5054-5062, 1999.
Latella, L, Sacchi, A, and Crescenzi, M (2000). Long-term fate of terminally differentiated skeletal muscle cells following E1A-initiated cell cycle reactivation. Cell Death Diff 7:145-154, 2000.
Latella, L, Sacco, A, Pajalunga, D, Tiainen, M, Macera, D, D'Angelo, M, Felici, A, Sacchi, A, and Crescenzi, M. Reconstitution of cyclin D1-associated kinase activity drives terminally differentiated cells into the cell cycle. Mol Cell Biol 21:5631-5643, 2001.
Bonapace, IM, Latella, L, Papait, R, Nicassio, F, Sacco, A, Muto, M, Crescenzi, M, and Di Fiore, PP. Np95 is regulated by E1A during mitotic reactivation of terminally differentiated cells and is essential for S phase entry. J Cell Biol 157:909-914, 2002.
Sacco, A, Pajalunga, D, Latella, L, Siepi, F, Rufini, A, and Crescenzi, M. Cell cycle reactivation in skeletal muscle and other terminally differentiated cells. In: Crescenzi, M (ed). Reactivation of the cell cycle in terminally differentiated cells. Kluwer Academic: New York, New York (2002). pp 45-61.
Sacco, A, Siepi, F, and Crescenzi, M. HPV E7 expression in skeletal muscle cells distinguishes initiation of the postmitotic state from its maintenance. Oncogene 22:4027-4034, 2003.
Camarda, G, Siepi, F, Pajalunga, D, Bernardini, C, Rossi, R, Montecucco, A, Meccia, E, and Crescenzi, M. A pRb-independent mechanism preserves the postmitotic state in terminally differentiated skeletal muscle cells. J Cell Biol 167:417-423, 2004.
Marchetti, A, Cecchinelli, B, D'Angelo, M, D'Orazi, G, Crescenzi, M, Sacchi, A, and Soddu, S. p53 can inhibit cell proliferation through caspase-mediated cleavage of ERK2/MAPK. Cell Death Differ 11:596-607, 2004.
Pajalunga, D, and Crescenzi, M. Regulation of cyclin E protein levels through E2F-mediated inhibition of degradation. Cell Cycle 3:1572-1578, 2004.
Pajalunga, D, Camarda, G, and Crescenzi, M. pRb in the differentiation of normal and neoplastic cells. In: Fanciulli, M (ed). Rb and tumorigenesis. Landes Bioscience/Eurekah.com: Georgetown, Texas (2006). pp 11-19.
Pajalunga, D, Mazzola, A, Salzano, AM, Biferi, MG, De Luca, G, and Crescenzi, M. Critical requirement for cell cycle inhibitors in sustaining nonproliferative states. J Cell Biol 176:807-818, 2007. Article
Pajalunga, D, Mazzola, A, Puggioni, E, and Crescenzi, M. Non-proliferation as an active state: conceptual and practical implications. Cell Cycle 6:1415-1418, 2007.
Pajalunga, D, Mazzola, A, Franchitto, A, Puggioni, E, and Crescenzi, M. Molecular and Cellular Basis of Regeneration and Tissue Repair: The logic and regulation of cell cycle exit and reentry. Cell Mol Life Sci 65:8-15, 2008.
Pajalunga, D, Puggioni, EM, Mazzola, A, Leva, V, Montecucco, A, and Crescenzi, M. DNA replication is intrinsically hindered in terminally differentiated myotubes. PLoS ONE 5:e11559, 2010. Article
Di Stefano, V, Giacca, M, Capogrossi, MC, Crescenzi, M, and Martelli, F. Knockdown of cyclin-dependent kinase inhibitors induces cardiomyocyte re-entry in the cell cycle. J Biol Chem 286:8644-8654, 2011.
De Luca, G, Ventura, I, Sanghez, V, Russo, MT, Ajmone-Cat, MA, Cacci, E, Martire, A, Popoli, P, Falcone, G, Michelini, F, Crescenzi, M, Degan, P, Minghetti, L, Bignami, M, and Calamandrei, G. Prolonged lifespan with enhanced exploratory behavior in mice overexpressing the oxidized nucleoside triphosphatase hMTH1. Aging Cell 12:695-705, 2013.
Falcone, G, Mazzola, A, Michelini, F, Bossi, G, Censi, F, Biferi, MG, Minghetti, L, Floridia, G, Federico, M, Musio, A, and Crescenzi, M. Cytogenetic analysis of human cells reveals specific patterns of DNA damage in replicative and oncogene-induced senescence. Aging Cell 12:312-315, 2013.
Biferi, MG, Nicoletti, C, Falcone, G, Puggioni, EM, Passaro, N, Mazzola, A, Pajalunga, D, Zaccagnini, G, Rizzuto, E, Auricchio, A, Zentilin, L, De Luca, G, Giacca, M, Martelli, F, Musio, A, Musaro, A, and Crescenzi, M. Proliferation of Multiple Cell Types in the Skeletal Muscle Tissue Elicited by Acute p21 Suppression. Molecular therapy : the journal of the American Society of Gene Therapy 23:885-895, 2015. Article
Pajalunga, D, Franzolin, E, Stevanoni, M, Zribi, S, Passaro, N, Gurtner, A, Donsante, S, Loffredo, D, Losanno, L, Bianchi, V, Russo, A, Rampazzo, C, and Crescenzi, M. A defective dNTP pool hinders DNA replication in cell cycle-reactivated terminally differentiated muscle cells. Cell Death Differ, 2017.
Galliot, B, Crescenzi, M, Jacinto, A, and Tajbakhsh, S. Trends in tissue repair and regeneration. Development 144:357-364, 2017.
Teveroni, E, Pellegrino, M, Sacconi, S, Calandra, P, Cascino, I, Farioli-Vecchioli, S, Puma, A, Garibaldi, M, Morosetti, R, Tasca, G, Ricci, E, Trevisan, CP, Galluzzi, G, Pontecorvi, A, Crescenzi, M, Deidda, G, and Moretti, F. Estrogens enhance myoblast differentiation in facioscapulohumeral muscular dystrophy by antagonizing DUX4 activity. J Clin Invest 127:1531-1545, 2017.
Pajalunga, D., and M. Crescenzi. 2021. Restoring the Cell Cycle and Proliferation Competence in Terminally Differentiated Skeletal Muscle Myotubes. Cells. 10.